• br Membrane receptor Indirect non genomic

  2021-05-21

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all tropisetron responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be acting

• br Introduction The cervix is a poorly studied

  2021-05-21

  

  Introduction The Phosphoramidon Disodium Salt is a poorly studied component of the mare’s reproductive tract. It has anatomical and biological defense mechanisms involved in the delicate balance between immunological tolerance, sperm transport and biological defense. Anatomically, the cervix is

• The different serotypes A G have unique receptors to which

  2021-05-21

  

  The different serotypes (A-G) have unique receptors to which they bind to produce the toxic effect on the nerve cells. (Lance, 2004, Rosetto et al., 2014). Intracellularly, the endopeptidase activity of different serotypes of BoNT target selectively a unique group of proteins, the SNARE Benzoylmesac

• br Significance Our understanding of the ubiquitin biology h

  2021-05-21

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• br The ubiquitin proteasome system The ubiquitin proteasome

  2021-05-21

  

  The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeostasis. By means of the UPS, Gemcitabine HCl can precisely and temporally degrade approximately 80% of the entire

• A different example of substrate dependent activation

  2021-05-21

  

  A different example of substrate-dependent activation is seen in CSN5, a JAMM-type DUB found in the eight subunit COP9 signalosome (CSN) [34]. The CSN deconjugates NEDD8 (neural precursor cell expressed developmentally downregulated 8) from Cullin Ring ubiquitin E3 ligases (CRLs). Through this activ

• It is well established that p

  2021-05-21

  

  It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause TAK-242 arrest and to repair cellular damage. There is growing evide

• Next the BE obtained for the different complexes were

  2021-05-21

  

  Next, the BE obtained for the different complexes were evaluated. From the BE obtained from our MD simulations, a very good binder can be differentiated from a very weak binder (−11.85 kcal/mol for MTX vs. −6.74 and −3.61 kcal/mol for compounds 14b and 15c, respectively) but ligands with similar bin

• MLN8237 Nitric oxide NO is synthesized by conversion of the

  2021-05-21

  

  Nitric oxide (NO) is synthesized by conversion of the l-arginine to NO and l-citrulline through reaction which is catalyzed by nitric oxide synthetase (NOS) (Knowles and Moncada, 1994). NO as an important molecule not only play a role as second messenger but also binds to cytochrome c oxidase and de

• Studies also provide evidence that cytokines such as TGF

  2021-05-21

  

  Studies also provide evidence that cytokines such as TGF-β, a TH3-type cytokine, may also play a role in airway remodeling. Data obtained by Cohen et al suggest that TGF-β1 can induce human BSMC proliferation by increasing the expression of IGFBP-3. Hence, the mitogenic action of TGF-β1 could be rel

• By using the C elegans Matrisome Annotator

  2021-05-20

  

  By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome Fenoprofen Calcium in these data sets. Thus, re-analyzing -omic datasets with the C. elegans Matrisome Annotator tool may be useful to generate novel hypotheses about the role of the C. elegans matrisome

• As for the molecular mechanism Ferguson BD suggested that Ep

  2021-05-20

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of Oleandrin australia with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expres

• Zaragozic Acid A The glycolytic pathway is a catabolic route

  2021-05-20

  

  The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO

• It has previously been established that

  2021-05-20

  

  It has previously been established that DDRs play an important role in collagen regulation in at least two distinct ways: (1) activation of DDRs by collagen results in up-regulation of the matrix metalloproteinases, which results in cleavage and degradation of the ECM20., 21., [22] and (2) orexin o

• br DDR receptor and MMP expression Type II

  2021-05-20

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

16021 records 669/1069 page Previous Next First page 上5页 666667668669670 下5页 Last page