• Treatment related adverse events have been a serious issue i

  2021-08-26

  

  Treatment-related adverse events have been a serious issue in clinical application. Severe toxicity has been reported in clinical trials using antibody blockade of CSF-1R (20 mg/kg), PD-1, and CTLA-4.29, 30, 31 However, apparent side effects were not observed in our study with PLX3397 treatment alon

• br Author contribution br Acknowledgements QNRF

  2021-08-26

  

  Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate

• Introduction br CK in the

  2021-08-26

  

  Introduction CK1 in the Regulation of Hh Pathway CK1 was initially identified as a negative regulator of Hh signaling at the level of transcription factor Ci by genetic studies in Drosophila and genome-wide RNAi screen in Drosophila cultured Puromycin aminonucleoside (Jia et al., 2005, Lum et a

• br Discussion Estradiol is known as one of the

  2021-08-26

  

  Discussion Estradiol is known as one of the stress signaling molecule [3,4,14]. Here, we showed that PH induced estradiol production before hepatocyte proliferation (Fig. 1). Conversely, the ovariectomized and orchitectomized mice produced less estradiol after PH, and had delayed liver regenerati

• Introduction Breast cancer is a highly prevalent

  2021-08-26

  

  Introduction Breast cancer is a highly prevalent malignancy. There are some recognized risk factors for breast cancer, like early menarche or late menopause, which increase the length of the exposure to hormones, as a result of a higher number of ovarian cycles [1]. Moreover, there is evidence supp

• br Discussion EFTs are sarcomas with almost

  2021-08-26

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular Demethoxycurcumin on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 imm

• In a recent report Yoshihara and colleagues used transcripto

  2021-08-26

  

  In a recent report, Yoshihara and colleagues (2016) used transcriptomes derived from freshly isolated islets of 2-week-old neonatal, 6-week-old young adult, or 12-week-old adult mice to interrogate how maturation is regulated to acquire glucose responsiveness. The authors observed that estrogen-rela

• Our data demonstrate that MPO increased ETRB

  2021-08-25

  

  Our data demonstrate that MPO increased ETRB mRNA expression, which translated into an increase in ETRB protein expression, which proved to be dependent on the enzyme's catalytic activity. Of importance, addition of MPO was sufficient to increase ETRB expression, revealing that endogenous (endotheli

• IL-4, murine recombinant Several of the keloid like lesions

  2021-08-25

  

  Several of the keloid-like lesions seen in these individuals were pigmented. It is of potential relevance that genetic variants in DDR1 [MIM: 600408] have been associated with vitiligo, and DDR1 activation is involved when IL-4, murine recombinant are attached to collagen-IV fibers. Because DDR1 an

• br Material and methods br Results

  2021-08-25

  

  Material and methods Results Discussion Isolated SKF38393 HCl receptor have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furtherm

• br EBV Infection Epstein Barr virus EBV human herpesvirus

  2021-08-25

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). Th

• Recent results from our group found

  2021-08-25

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet orexin receptor to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva are resolvin

• A previous study suggested that DARs and

  2021-08-25

  

  A previous study suggested that DARs and octopamine/tyramine receptors (OARs/TARs) have close pharmacological properties (Beggs et al., 2011). Their relationships were also supported by phylogenetic analyses (Balfanz et al., 2005, Hauser et al., 2008, Wu et al., 2014), indicating that some of DAR an

• aminolevulinic acid mg It is of interest to consider

  2021-08-25

  

  It is of interest to consider an explanation for the apparent phosphorylation of hSSB1 in undamaged cells. One such may be that in order to execute a rapid response to replication inhibition, basal S134 phosphorylation could function to keep hSSB1 in a ‘primed’ state prior to stress. Such an arrange

• In addition to demonstrating the importance of

  2021-08-25

  

  In addition to demonstrating the importance of DNMTs, we show that TGFβ1 differentially regulated DNMTs, and that TGFβ1 is both necessary and sufficient to induce lineage conversion of hepatocytes into MLCs with phenotypes and multipotency resembling MSCs. Upon withdrawal of TGFβ1 on day 28, we obse

16022 records 618/1069 page Previous Next First page 上5页 616617618619620 下5页 Last page