• 5-hme-CTP Animal studies have shown that various antidepress

  2021-11-24

  

  Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key 5-hme-CTP regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative f

• Although GABA C receptors were originally described

  2021-11-24

  

  Although, GABA-C receptors were originally described in the spinal cord [16], clues to their physiological function arise mainly from studies in the visual system [5], [26]. In mammals, GABA-C receptors are found abundantly in cone photoreceptors and bipolar cell axon terminals, where they participa

• To validate that our natural experiment operates primarily t

  2021-11-24

  

  To validate that our natural experiment operates primarily through a large negative shock to the risk-taking incentives provided by option compensation measured by vega, we do two sets of tests. First, we confirm a significant drop in vega after the adoption of FAS 123R for treated firms relative to

• In human cancers it has been identified that FOXC AS

  2021-11-24

  

  In human cancers, it has been identified that FOXC2-AS1 functions as an oncogenic RNA. For instance, in osteosarcoma, FOXC2-AS1 regulates the expression of FOXC2 at the transcription and post-transcription levels to promote doxorubicin resistance by facilitating ABCB1 expression (C.L. Zhang et al.,

• The IN gene of the HIV

  2021-11-24

  

  The IN gene of the HIV isolate from Papua (CRF01_AE isolate) contains genetic polymorphisms (Fig. 1A) that encode for variant amino acids in the IN protein, based on the Stanford HIVdb mutation interpretation database (Fig. 1B). These variations slightly changed the three-dimensional structure of IN

• In Kdm c germline and

  2021-11-24

  

  In Kdm5c germline and forebrain conditional knockout mice, RNA sequencing showed the upregulation of a large set of genes, suggesting that Kdm5c functions primarily as a transcriptional repressor [,]. While no changes in global H3K4me3 levels were observed in the knockout neurons, there were thousan

• Despite such extensive analysis of Gcn

  2021-11-24

  

  Despite such extensive analysis of Gcn5 homologs, the function of C. albicans Gcn5 (CaGcn5) is not well understood. Therefore, in this study we investigated the role of CaGcn5 in filamentous growth, invasive growth and stress response of C. albicans. We also examined the subcellular distribution of

• The neurotransmitter histamine plays a key role in the

  2021-11-24

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in MG-262 histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease and depres

• vorapaxar Multiple subsets of Breg cells in mice have been

  2021-11-24

  

  Multiple subsets of Breg cells in mice have been identified that could suppress the T cell-mediated response. However, a lack of consensus surface markers for Breg cells made it difficult to judge whether Breg cells are a special B cell subset or whether all vorapaxar have an immuno-regulatory funct

• Different crystal structures of both HOs were reported and

  2021-11-24

  

  Different crystal structures of both HOs were reported and showed that the three-dimensional structures of proteins (HO-1: PDB code 1N45, HO-2: PDB code 2QPP) are predominantly in an α-helical conformation, with the heme packed between two helices (distal and proximal), and present a remarkable stru

• The overall characteristic of RNA profile of Leydig cell

  2021-11-24

  

  The overall characteristic of RNA profile of Leydig cell is still a mystery. Variation in total RNA will cause subsequent difference in protein expression and phenotypic modulation [16]. In this study, we used a murine nicotine exposure model coupled with next generation RNA sequencing (NGS) and fou

• Treatment and control for IBD

  2021-11-24

  

  Treatment and control for IBD are targeted to identify and eliminate the cause if possible, decrease intestinal inflammation, reduce diarrhea and vomiting, improve appetite, and promote weight gain. Methods include dietary manipulation with or without concurrent medical therapy such as corticosteroi

• Cytidine 5-triphosphate br Effect http www apexbt com media

  2021-11-24

  

  Effect of HDACi on Proteasomal Regulation of IκBα and p65 Levels At the transcriptional level, expression of CXCL8, as well as many other proinflammatory chemokines, is regulated by the transcription factor NFκB, which is constitutively activated in solid cancers, including OC, lung, and breast c

• The physiological role of lactate induced

  2021-11-23

  

  The physiological role of lactate-induced antilipolytic effects is less clear. It has been speculated that GPR81 mediates the inhibition of lipolysis during intensive exercise, a condition which results in high systemic lactate plasma concentrations 9, 10. Owing to oxygen shortage resulting from int

• The endocannabinoid system ECS consists of cannabinoid CB

  2021-11-23

  

  The endocannabinoid system (ECS) consists of cannabinoid (CB)1 and CB2 receptors, their endogenous ligands anandamide and 2-arachidonylglycerol, and the synthesizing and degrading enzymes for these ligands. Cannabinoids and the ECS are involved in the regulation of GI motility in physiological and p

16089 records 566/1073 page Previous Next First page 上5页 566567568569570 下5页 Last page