• Although GLP has greater insulin releasing

  2022-08-18

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• br Author contributions br Transparency

  2022-08-18

  

  Author contributions Transparency document Acknowledgments The financial contributions of the Marie-Curie Action: BIOCONTROL, contract number MCRTN – 33439, the Agence Nationale de la Recherche (projects membraneDNP 12-BSV5-0012, MemPepSyn 14-CE34-0001-01, InMembrane 15-CE11-0017-01 and the

• Ning et al showed that LPC appeared

  2022-08-18

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• Moreover long term treatment of leukemia cells

  2022-08-18

  

  Moreover, long term treatment of leukemia cells with imatinib activates AKT, ERK and STAT5 signaling pathway and induce upregulation of EZH2 protein in patients with CML, Ph + ALL and human eosinophilic leukemia cell line (EOL-1 cells) [142]. So, resistance to tyrosine kinase inhibitor (TKI) imatini

• Introduction Histamine Imidazolyl ethylamine is an important

  2022-08-17

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric Mevastatin secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exerts

• br Histamine and glycaemia Histamine is

  2022-08-17

  

  Histamine and glycaemia Histamine is involved in a wide variety of pathophysiological events mostly related to the inflammatory response through four receptors, namely H1-4Rs. The first studies of Nicardipine HCl mg and diabetes date back to the 1950s. Since that time the involvement of histamine

• These agents can be divided

  2022-08-17

  

  These agents can be divided into three categories based upon the therapeutic agent conjugated to the antibody; the most frequently explored are ADCs using a cytotoxic agent to be delivered directly to the tumor site. The second class has not been broadly used and consists of radionucleotides (Wong e

• Introduction The onset of uterine labor

  2022-08-17

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• br Conclusions Beta cell specific

  2022-08-17

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta mk2206 or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other ce

• Niacin nicotinic acid is widely used

  2022-08-17

  

  Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing

• The Growth Hormone Secretagogue Receptor GHSR also known as

  2022-08-17

  

  The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in LY3009120 regions concerned with homeostatic and motivational function such as the hypothalamus,

• br Results and discussion The synthesis of core

  2022-08-16

  

  Results and discussion The synthesis of core aldehyde building block 2 commenced with known aldehyde 5. The Horner–Wadsworth-Emmons olefination of the latter (using commercially available 6) gave cinnamate ester 7. Facile hydrogenation of the double bond in 7 was achieved over Raney nickel withou

• Considering the conformational preferences of the SRSRY sequ

  2022-08-16

  

  Considering the conformational preferences of the SRSRY sequence in the x-ray structures of soluble uPAR (SuPAR) [18], [19], [20], [50], [51], it is included in a quite flexible linker delimited by Cys76 and Cys95 residues. The SRSRY sequence adopts either α-turned or β-extended conformation. In any

• br Importance of iron and lipoxygenase in ferroptosis What

  2022-08-16

  

  Importance of iron and lipoxygenase in ferroptosis What remains to be somewhat controversial is the role of iron and lipoxygenases (LOX) in the death process, specifically in lipid peroxidation. So far, iron chelators have been repeatedly shown to halt ferroptosis (hence its name) induced by chem

• Treatment with histamine had no effect on histamine H

  2022-08-16

  

  Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 Caspase-4 Colorimetric Assay Kit sale (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor r

15336 records 363/1023 page Previous Next First page 上5页 361362363364365 下5页 Last page