• Last decade has provided a number

  2023-11-09

  

  Last decade has provided a number of studies indicating that AhR signaling could play a role both in the development and in progression of multiple cancer types, with potential implications for cancer therapy (for review see (Kolluri et al., 2017; Murray et al., 2014)). Activation of AhR is consider

• br Introduction Psychostimulant abuse and

  2023-11-09

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• A role for YAP in mediating resistance to EGFR inhibition

  2023-11-09

  

  A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali

• br Research perspective In vitro and in vivo studies

  2023-11-09

  

  Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron

• We have shown that an

  2023-11-08

  

  We have shown that an extensive region in SERBP1 (amino acids 354 to 474, using co-ordinates based on the full-length isoform, Figs. 1a and 2) is necessary for it to interact with RACK1; since this region has substantial homology to the corresponding region of HABP1 (Fig. 3) it is a reasonable hypot

• 4-DAMP Finally intracrine androgen synthesis metabolism can

  2023-11-08

  

  Finally, intracrine androgen synthesis/metabolism can be activated thus allowing 4-DAMP to bypass the low levels of androgens in the circulation by producing androgens themselves (Cai and Balk, 2011, Rahman et al., 2004). Moreover, changes in AR co-regulators like the overexpression of steroid recep

• br Introduction The development and plasticity of synapses i

  2023-11-08

  

  Introduction The development and plasticity of synapses involve the timely recruitment of a plethora of proteins on both pre- and postsynaptic sides through ill-defined mechanisms. At excitatory synapses, two of the major proteins that are dynamically recruited postsynaptically are the Ca2+/calmo

• The rescue of the behavioral deficit

  2023-11-08

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the hepititis b of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. Confirming pr

• br Glioblastoma GBM is the

  2023-11-08

  

  Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of Apamin synthesis tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with chemoth

• The random zero offset of accelerometer and

  2023-11-08

  

  The random zero offset of accelerometer and gyroscope estimated by two-step observation update Kalman filter are shown in Table 2, one group of estimated results is shown in Fig. 3. Contrast with the data from Eq. (23) and the ones from Fig. 3 and Table 2, it can be seen that the random zero offset

• Firms are subject to corporate taxation and face either

  2023-11-08

  

  Firms are subject to corporate taxation, and face either an ACE or a CBIT tax scheme. The two tax regimes achieve financing neutrality by treating debt and equity equally, but differ according to whether deduction of capital costs from the corporate tax IY-5511 synthesis is allowed or not. While AC

• This study does have several limitations mainly related

  2023-11-08

  

  This study does have several limitations, mainly related to the DMSO vehicle. While DMSO is a known anti-inflammatory mediator,5, 12 it has been shown to upregulate ALOX5, which was not seen in this study (as we are likely underpowered to detect this difference). A manifestation of this anti-inflamm

• br Experimental procedure br Introduction

  2023-11-08

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Cryptochlorogenic acid Although CP has been an important res

  2023-11-08

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular Cryptochlorogenic acid by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an invo

• br Experimental procedures br Results br Discussion Although

  2023-11-07

  

  Experimental procedures Results Discussion Although previous studies have indicated that astrocyte aromatase plays a role in nociceptive processes (O'Brien et al., 2015, Smeester et al., 2016), the mechanisms responsible for the regulation of aromatase and its involvement in nociception rem

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